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CorFlux software has potential to save patients from aortic rupture

Oct 12, 2023

Hand holding a phone, stethoscope on the background

No one has successfully developed a way to assess whether a weakened area of the aorta will rupture. CorFlux may change this global healthcare challenge with software under development. The CorFlux team has been selected as part of the Health Incubator Helsinki 2023 incubator program.

A thoracic aortic aneurysm is a weakened area in the large artery that carries blood from the heart through the chest and torso. This area may bulge and rupture resulting in internal bleeding, which is almost always fatal. Fortunately, for the majority of patients the aneurysm remains stable. Unfortunately, there is no risk assessment tool to separate patients with low rupture risk from patients with moderate to high rupture risk. CorFlux business developer, Tero Puustinen, shares the current situation, “Every aortic aneurysm patient is followed up with expensive and time-consuming medical imaging, placing a burden on global healthcare, with an annual expenditure exceeding 3 billion euros worldwide”. Even with this follow-up, many patients die before reaching the medical benchmark at which point preventive (and therefore life-saving) surgery is even considered. The CorFlux aortic aneurysm rupture risk analysis software will utilize numerical algorithms aimed to create an accurate risk assessment, decreasing the amount of follow-ups for low-risk patients, and shifting resources to save moderate-to-high risk patients.

Diverse in-depth expertise to maximize success

The CorFlux team came to be when adjunct professor in mathematics, Matti Kurki, discussed  calculations related to the aorta with his friend. He was advised to get in touch with cardiologist and professor, Marja Hedman, who was – and is-  leading a research group specializing on aortic aneurysms. Several fruitful discussions eventually led to the innovation, which eventually led to the formation of a multi-professional team with expertise in cardiology, heart surgery, physics, mathematics as well as commercialization, regulation and software development. The CorFlux team is currently working together with universities and physicians to completely change the aneurysms field. In addition to organic networks, through the Health Incubator Helsinki program, CorFlux team also utilizes expertise of other esteemed professionals from the healthcare industry who offer valuable advice on strengthening their business proposition, ensuring financial stability, and establishing a network of advisors.

CorFlux Team
Nora Rauhala, Pasi Karjalainen, Matti Kurki, Marja Hedman, Saara Sillanmäki and Tero Puustinen

CorFlux technology will be made scalable, with new directions in mind from the beginning

The implications of CorFlux’s aortic rupture risk assessment software could be revolutionary, and totally unique. No one in the world has come up with a solution to this unmet medical need, and this is just the beginning for the team. Health Incubator Helsinki is there to support the team in this critical period, providing guidance for making their business case solid and sustainable. With personalized strategies to go-to-market and stay-on-market, the CorFlux team may expand their product to additionally evaluate the rupture risk of abdominal aortic aneurysms in the future, potentially tripling the markets with over 15 million abdominal aortic aneurysm patients globally.

Health Incubator Helsinki’s knowledge and ambition prevent typical business pitfalls

The CorFlux team applied to the Health Incubator Helsinki program to gain insight on the commercialization of health and medical startups. Although the team is currently in the commercialization phase, they are considering establishing CorFlux as a company. In the meantime, the team is fully taking advantage of the Health Incubator Helsinki program’s expert advisors, business services, founder talks, demo days and regular workshops and webinars which cover a wide range of topics chosen to prepare teams and startups in key business areas like brand building and investment strategies. The teams get peer to peer support from the other incubator teams with similar interest, as well. With all the support from the program and fellow health innovators, Puustinen expects the transition from research to business to be smooth, “When the road twists and turns, great coaching and sparring will help you drive much faster.” To get in touch with the next potential Finnish unicorn, use the contact information below!

CorFlux contact information: tero.puustinen@uef.fi

Logo of CorFlux

Startup Fast Facts

Name: CorFlux

Tech in one sentence: Computational tool that aims to give an estimate of the risk of aortic rupture.

Product: Clinical software for the assessment of the risk of rupture due to an aneurysm

Target market launch: After CE approval approximately 2025

Founded: Research to business project funded by Business Finland project since 2022

Team size: 7

Website: https://uefconnect.uef.fi/tutkimusryhma/corflux/

Funding raised: 650 000€ Business Finland research to business grant

Text: Rita Turpin, Giuliano Didio

Photos: Tero Puustinen / CorFlux, Pixabay